Pharmacokinetics (PK)and
Toxicokinetics (TK) Services
Drug Absorption, Distribution, Metabolism, Excretion (ADME) and Kinetics
Comprehensive analysis of how a drug moves through the body, including studies for single, multiple, and cassette dosing.
Dose Response and Linearity:
Determining dose escalation and range-finding studies to understand the relationship between dose and effect.
Tissue Distribution
Investigating where a substance goes in the body, including distribution in organs like the brain, heart, liver, lung, kidney, and ocular tissues (aqueous humor, vitreous humor, lens, cornea, optic nerve).
PK Parameter Determination
Calculating key pharmacokinetic parameters such as maximum plasma concentration (Cmax), time to reach Cmax (Tmax), area under the curve (AUC), clearance rates, oral bioavailability, and volume of distribution.
Blood-Brain Barrier Studies
Assessing a substance’s ability to cross the blood-brain barrier.
Continuous Infusion PK
Evaluating the pharmacokinetics of continuously infused compounds.
